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Time-lapse confocal imaging of neuronal
dendrites in live, developing hippo-campal tissue slices revealed
rapid and dramatic changes in the structure of postsynaptic spine-like
protrusions. The illustration depicts a fluorescently labeled
CA1 pyramidal neuron (white cell) with developing dendrites in a live
tissue slice derived from a neonatal rat. The higher-magnification
color images, progressing in a time sequence from left to right (5
min intervals), reveal changes in the structure of individual spiny
protrusions along a segment of dendrite from the cell shown.
Such dynamic changes in dendritic structure during development may
contribute to the formation and plasticity of synaptic contacts with
axons.
See: Michael E. Dailey and Stephen J Smith. "The
dynamics of dendritic structure in developing hippocampal slices".
Journal of Neuroscience. 1996 May 1;16(9):2983-94.
Abstract Full
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