The University of Iowa
College of Liberal Arts and Sciences
The Department of Biology

Faculty Information

Maurine Neiman

Maurine Neiman

Assistant Professor
Ph.D., Indiana University 2004
324B BB
(319) 384-1814
maurine-neiman@uiowa.edu

http://www.biology.uiowa.edu/neiman
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Evolution of sexual reproduction and ploidy level

WHY IS SEXUAL REPRODUCTION SO COMMON?
Sexual females produce both sons and daughters, while asexual females make only daughters. Since only females produce offspring, this "cost of males" predicts that sex should be rare because asexual females will leave many more descendants than will sexual females. In reality, however, sex predominates. Despite years of study, why sex is so common remains unclear, and is considered one of the most important unanswered questions in evolutionary biology.

A clear understanding of the advantages of sex, which is distinguished from asexuality by the production of genetically variable offspring, is also of direct relevance to understanding the value of preserving genetic diversity within and among populations, species, and ecological communities. More broadly, our research program is relevant to scientists who use our snail study system as a model for ecotoxicology as well as those studying the causes and consequences of biological invasions. Our lab group is also very committed to mentoring and community engagement, and we are involved in a variety of such efforts, from regular collaborations with 10th grade Biology students at a local high school to the development and testing of a genomics module for a national high school computer science curriculum to our central role in organizing the annual Iowa City Darwin Day celebrations.

HOW ARE SEXUALS AND ASEXUALS DIFFERENT?
The expectation that sex should be rare is based on the assumption that sexuals and asexuals are similar. In other words, the two-fold cost of sex will be diminished or even negated if asexual females experience disadvantages that negatively affect their ability to produce daughters. Accordingly, our research is focused on the many ways in which asexuals and sexuals might differ.

RESEARCH PROJECTS
Many research projects in our lab use Potamopyrgus antipodarum, a freshwater snail native to New Zealand. Natural lake populations of this snail vary in the frequency of obligately sexual and obligately asexual individuals, which sets the stage for investigation of why sex persists in some populations but not others. This species has been the focus of research into the maintenance of sex for nearly 20 years, and is now the best-characterized natural system available for studying why sexual reproduction is so common. While our research is based in evolution, we bring together ideas and tools from across biology to study sex in P. antipodarum. Several of the main research themes in our lab are outlined below.

Genetic and genomic consequences of asexuality. One set of projects revolves around testing the hypothesis that asexuality is rare at least in part because sex is required to prevent the accumulation of harmful mutations and facilitate the spread of beneficial mutations. We are using a variety of genetic and genomic approaches to address these questions in P. antipodarum. Related projects assess whether mutation accumulation in asexual P. antipodarum has detectable negative effects.

Potamopyrgus antipodarum genome project. We are leading an NSF-funded genome sequencing project for P. antipodarum, in collaboration with John Logsdon (U. Iowa) and Jeffrey Boore (UC-Berkeley). This project promises to provide unique and important new insights into how sexual reproduction and ploidy-level variation influence the evolution of genome composition and structure.

Disadvantages of polyploidy. Another major research focus in our lab is centered on the consequences of the higher ploidy of asexual vs. sexual snails. Like most sexual organisms, sexual P. antipodarum have two chromosome sets, while asexual P. antipodarum (like most asexuals) have at least three. Changes in ploidy level can dramatically affect key organismal traits such as cell size, body composition, and growth rate. Thanks to funding from the National Geographic Society and the Research Council of Norway, we are currently addressing whether these possible consequences of polyploidy affect asexual P. antipodarum in a manner that could help compensate for the costs of sex and/or influence the distribution of ploidy level variation within and across natural populations.

Generation and maintenance of genome size variation. There is remarkable variation in eukaryotic genome size and structure. Why and how this variation is generated and maintained is not clear, though both adaptive (selection) and non-adaptive processes (e.g., mutation, drift) are likely to play a role. We have found that Potamopyrgus antipodarum harbors extensive genome size variation even within ploidy levels, and are working in collaboration with departmental colleagues Prof. Robert Malone and Prof. Sarit Smolikove to uncover the causes and consequences of this variation.

Population dynamics of asexuals. We have also used laboratory experiments to demonstrate that asexual females have a negative impact on one another's reproduction. We are conducting research into snail behavior and population ecology to better understand why and how this happens, especially in light of the fact that P. antipodarum is invading freshwaters in Europe, Australia, and North America. Since the invasive populations are nearly all asexual, our research can provide new understanding of invasion dynamics as well as sex, and perhaps inspire ideas about how better to control the invading populations.

Graduate Students:
I will consider taking new graduate students for the fall of 2014:

Prospective graduate students with interests in evolutionary biology and especially the evolution and ecology of sex and ploidy level/genome size variation who would like to consider joining my lab should email me (maurine-neiman@uiowa.edu) to discuss the possibility of applying to the graduate program.

Click on a thumbnail to view image and description:
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Figure 1
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Figure 2
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Figure 3


Selected Publications

Krist, A. C., A. D. Kay, K. Larkin, and M. Neiman. 2013. Response to phosphorus limitation varies among lake populations of the freshwater snail, Potamopyrgus antipodarum. PLoS ONE, in press.

Krois, N., A. Cherukuri, N. Puttagunta, and M. Neiman. 2013. Higher rate of tissue regeneration in polyploid asexual vs. diploid sexual freshwater snails. Biology Letters 9: 20130422.

Paczesniak, D., J. Jokela, K. Larkin, and M. Neiman. 2013. Discordance between nuclear and mitochondrial genomes in sexual and asexual lineages of the freshwater snail Potamopyrgus antipodarum. Molecular Ecology 22: 4695-4710.

Zachar, N., and M. Neiman. 2013. Profound effects of population density on fitness-related traits in an invasive freshwater snail. PLoS ONE 8: e80067.

Neiman, M., A. D. Kay, and A. M. Krist. 2013. Sensitivity to phosphorus limitation increases with ploidy level in a New Zealand snail. Evolution 67: 1511-1517.

Neiman, M., D. Warren, B. Rasmussen, and S. Zhang. 2013. Complex consequences of increased density for reproductive output in an invasive freshwater snail. Evolutionary Ecology 27: 1117-1127.

Wilton, P. R., D. B. Sloan, J. M. Logsdon, Jr., H. Doddapaneni, and M. Neiman. 2013. Characterization of transcriptomes from sexual and asexual lineages of a New Zealand snail (Potamopyrgus antipodarum). Molecular Ecology Resources 13:289-294.

Neiman, M., A. D. Kay, and A. M. Krist. 2013. Can resource costs of polyploidy provide an advantage to sex? Heredity 110:152-159.

Soper, D. M., M. Neiman, O. P. Savytskyy, M. E. Zolan, and C. M. Lively. 2013. Spermatozoa production by triploid males in the New Zealand freshwater snail Potamopyrgus antipodarum. Biological Journal of the Linnean Society 110: 227-234.

Forbes, A. A., L. Rice, N. B. Stewart, W. L. Yee, and M. Neiman. 2013. Phenotypic evolution, niche differentiation, and host shifting in an asexual parasitic wasp. Journal of Evolutionary Biology 26: 1330-1340.

Neiman, M., K. Larkin, A. R. Thompson, and P. Wilton. 2012. Male offspring production by asexual Potamopyrgus antipodarum, a New Zealand snail. Heredity 109:57-62.

King, K. C., O. Seppälä, and M. Neiman. 2012. Is more better? Polyploidy and parasite resistance. Biology Letters 8: 598-600.

Neiman, M., D. Paczesniak, D. M. Soper, A. T. Baldwin, and G. Hehman. 2011. Wide variation in ploidy level and genome size in a New Zealand freshwater snail with coexisting sexual and asexual lineages. Evolution 65:3202-3216.

Neiman, M., and T. Schwander. 2011. Using parthenogenetic lineages to identify advantages of sex. Evolutionary Biology 38:115-123.

Nelson, A. E., and M. Neiman. 2011. Persistent copulation in asexual female Potamopyrgus antipodarum: evidence for male control with size-based preferences. International Journal of Evolutionary Biology 2011:439046.

Neiman, M., G. Hehman, J. T. Miller, J. M. Logsdon, Jr., and D. R. Taylor. 2010. Accelerated mutation accumulation in asexual lineages of a freshwater snail. Molecular Biology and Evolution 27: 954-963.

Hessen, D. O., P. D. Jeyasingh, M. Neiman, and L. J. Weider. 2010. Genome streamlining and the elemental costs of growth. Trends in Ecology and Evolution 25:75-80.

Neiman, M., S. Meirmans, and P. Meirmans. 2009. What can asexual lineage age tell us about the maintenance of sex? Annals of the New York Academy of Sciences 1168: 185-200.

Neiman, M., K. M. Theisen, M. E. Mayry, and A. D. Kay. 2009. Can phosphorus limitation contribute to the maintenance of sex? A test of a key assumption. Journal of Evolutionary Biology 22: 1359-1363.

Neiman, M. and D. R. Taylor. 2009. The causes of mutation accumulation in mitochondrial genomes. Proceedings of the Royal Society of London B, doi:10.1098-rspb.2008.1758.

Neiman, M. 2006. Embryo production in a parthenogenetic snail (Potamopyrgus antipodarum) is negatively affected by the presence of other parthenogens. Invertebrate Biology 125: 45-50.

Neiman, M. and T. A. Linksvayer. 2006. The conversion of variance and the evolutionary potential of restricted recombination. Heredity 96: 111-121.

Neiman, M., J. Jokela and C. M. Lively. 2005. Variation in asexual lineage age in Potamopyrgus antipodarum, a New Zealand snail. Evolution 59:1945-1952.

Barr, C., M. Neiman and D. R. Taylor. 2005. Inheritance and recombination of mitochondrial genomes in plants, fungi and animals. New Phytologist 168:39-50.

Neiman, M. and C.M. Lively. 2004. Pleistocene glaciation is implicated in the phylogeographical structure of Potamopyrgus antipodarum, a New Zealand snail. Molecular Ecology 13:3085-3098.

Busch, J.W., M. Neiman and J.M. Koslow. 2004. Evidence for maintenance of sex by pathogens in plants. Evolution 58:2584-2590.

Neiman, M. 2004. Physiological dependence on copulation in parthenogenetic females can reduce the cost of sex. Animal Behaviour 67:811-822.