The University of Iowa
College of Liberal Arts and Sciences
The Department of Biology

Faculty Information

David Soll

David Soll

Professor
Ph.D., University of Wisconsin-Madison 1970
302 BBE
(319) 335-1117
david-soll@uiowa.edu
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Molecular Pathology and Cell Motility

Our research focuses on three aspects of human disease. First, we are interested in understanding the role phenotypic switching plays in yeast infections. In 1987, the white-opaque transition was identified in a strain of Candida albicans isolated in a blood stream infection at Iowa. Recently, it was discovered that this phenotypic transition is an essential step in C. albicans mating, and unique signaling occurs between opaque and white cells. Opaque cells signal white cells to form a tissue (a biofilm) that facilitates mating between opaque cells. We are actively elucidating the molecular mechanisms that regulate this transition. Second, we are interested in the defects in motility and chemotaxis resulting in human disease. Using a combination of computer-assisted motion analysis techniques, fluorescence microscopy, and molecular genetic techniques, we are analyzing the role of cation receptors in cell motility and chemotaxis in the model system Dictyostelium discoideum and metastatic cancer cells. Finally, we have begun work on generating monoclonal antibody chips to identify the subgroups of the major cancers of humans and the identification of new cancer stem cell surface markers, since these cells have been implicated in cancer recurrence.

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Figure 1


Selected Publications

Yi, S., Sahni, N., Daniels, K.J. Lu, K.L., Huang, G., Garnass, A.M., Pujol, C., Srikantha, T. and Soll, D.R. 2011. Utilization of the Mating Scaffold Protein in the Evolution of a New Transduction Pathway for Biofilm Development. mBio, 2(1): doi:10.1128/mBio. 00237-10.

Lusche, D. F., Wessels, D., Ryerson, D. E., Soll, D. R. 2011. Nhe1 is Essential for Potassium but Not Calcium Facilitation of Cell Motility and the Monovalent Cation Requirement for Chemotactic in Dictyostelium discoideum. Euk. Cell., 10(3) doi:10.1128/EC.00255-10: 320-331.

Soll, D. R. 2011. Switching and Mating. Chapter V. Candida and Candidiasis. (Eds.: CJ. Clancy and R.A. Calderone). ASM Press.

Soll, D.R. 2010. The evolution of a new signal transduction pathway in Candida albicans. Trends in Microbiology., doi:10 1016/j.tim 2010 10.001.

Scherer A, Kuhl S, Wessels, D., Lusche D. F., Raisley B, Soll DR. 2010. Ca2+ chemotaxis in Dictyostelium discoideum. J. Cell Sci. 123: 3756-3767.

Sahni N., Yi S., Daniels K.J., Huang G., Srikantha T., and Soll D.R. 2010. Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways. PLoS. Biol. 8: e1000363.

Huang, Guanghua and Soll, D. R. 2010. N-Acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog. 6(3): e1000806. doi:10.1371/journal.ppat.1000806.

Breshears, L.M., Wessels, D., Soll, D.R. and Titus, M.A. 2010. An unconventional myosin required for cell polarization and chemotaxis. Proc. Nath. And Science (USA 107, 6918- 6923).

Sahni, N., Yi, S., Daniels, K. J., Srikantha, T., Pujol, C. and Soll, D. R. 2009. Genes selectively up-regulated by pheromone in white cells are involved in white cell biofilm formation in Candida albicans. PLoS Pathog. 2009 Oct; 5(10):e1000601

Soll, D. R. 2009. Why Does Candida albicans Switch? 2009. FEMS Yeast Res. 1-17.

Lusche, D., Wessels, D. and Soll, D. R. 2009. The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis and the cortical localization of myosin II in Dictyostelium discoideum. Cell Motil Cytoskeleton, 66(8): 567-87.

Butler, G. et al. 2009. Evolution of pathogenicity and sexual reproduction revealed by comparing eight Candida genomes. Nature, 459: 657-62

Huang, G., Srikantha, T., Sahni, N., Song, Y. and Soll, D. R. 2009. CO2 regulates white-opaque switching in Candida albicans. Curr. Biol., 19: 1-5.

Yi, S., Sahni, N., Pujol, C., Daniels, K. J., Srikantha, T., Ma, Ning and Soll, D. R. 2009. A Candida albicans-specific region of the -pheromone receptor plays a selective role in the white cell pheromone response. Molec. Microbiol., 71: 9926-947.

Yi S, Sahni N, Daniels KJ, Pujol C, Srikantha T, Soll DR. 2008. The Same Receptor, G-Protein and MAP Kinase Pathway Activate Different Downstream Regulators in the Alternative White and Opaque Pheromone Responses of Candida albicans. Mol Biol Cell., 19:957-970